発表論文 Published Papers

【英文雑誌】
Sakakura K, Takahashi H, Motegi SH, Yokobori-Kuwabara Y, Oyama T, ChikamatsuK.
Immunological features of circulating monocyte subsets in patients with squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌患者における循環血中単球サブセットの免疫学的特徴)
Manuscript in preparation.(投稿中)[corresponding author]

■Kawada T, Takahashi H, Sakakura K, Ida S, Mito I, Toyoda M, Chikamatsu K.
Circulating tumor cells in patients with head and neck squamous cell carcinoma: Feasibility of detection and quantitation.
(頭頸部扁平上皮癌患者における循環腫瘍細胞:検出と定量の可能性)
Head Neck. 2017 Nov;39(11):2180-2186. doi: 10.1002/hed.24893. Epub 2017 Aug 17.

■Takahashi H, Sakakura K, Kudo T, Toyoda M, Kaira K, Oyama T, Chikamatsu K.
Cancer-associated fibroblasts contribute to establishing the tumor immune microenvironment through the induction and accumulation of M2 macrophages.
(癌関連線維芽細胞はM2マクロファージの誘導と集積によって腫瘍微小環境を形成する)
Oncotarget, Jan 31;8(5):8633-8647. doi: 10.18632/oncotarget.14374.

Sakakura K, Tazawa M, Kosuge N, Takagi M, Morita M, Kurosaki M, Chiyoda T, Kanai Y, Endo A, Murata T, Shino M, Yokobori Y, Shirakura K, Wada N, Chikamatsu K.
Impact of a multidisciplinary round visit for the management of dysphagia utilizing a Wi-Fi-based wireless flexible endoscopic evaluation of swallowing.
(Wi-Fiを用いたワイヤレス内視鏡による嚥下機能評価を利用した多職種嚥下回診の効果)
Ann Otol Rhinol Laryngol. 2017 Jan;126(1):47-53. [corresponding author]

Sakakura K, Takahashi H, Kaira K, Toyoda M, Murata T, Ohnishi H, Oyama T, Chikamatsu K.
Relationship between tumour-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumour microenvironment.
(頭頸部扁平上皮癌の腫瘍微小環境におけるCD47発現と腫瘍関連マクロファージとの関連)
Lab Invest. 2016 Sep;96(9):994-1003. doi: 10.1038/labinvest.2016.70. [corresponding author]

■Takahashi H, Sakakura K, Mito I, Ida S, Chikamatsu K.
Dynamic changes in immune cell profile in head and neck squamous cell carcinoma: immunomodulatory effects of chemotherapy.
(頭頸部扁平上皮癌の免疫細胞プロファイルの変化:化学療法による免疫調節効果)
Cancer Sci. 2016 Aug;107(8):1065-71. doi: 10.1111/cas.12976.

■Kaira K, Toyoda M, Shimizu A, Imai H, Sakakura K, Nikkuni O, Suzuki M, Iijima M, Asao T, Chikamatsu, K.
Decreasing expression of glucose-regulated protein GRP78/BiP as a significant prognostic predictor in patients with advanced laryngeal squamous cell carcinoma.
(進行喉頭扁平上皮癌患者における予後因子としてのブドウ糖調節蛋白GRP78/BiPの減少)
Head Neck. 2016 Oct;38(10):1539-44. doi: 10.1002/hed.24471.

■Kaira K, Toyoda M, Shimizu A, Imai H, Sakakura K, Suzuki ON, Iijima M, Asao T, Chikamatsu K.
Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma.
(ステージⅢ/Ⅳ下咽頭扁平上皮癌患者の予後におけるGRP78/BiP発現の重要性)
Neoplasma. 2016;63(4):588-94. doi: 10.4149/neo_2016_412.

■Yokobori Y, Toyoda M, Sakakura K, Kaira K, Tsushima Y, Chikamatsu K.
18F-FDG uptake on PET correlates with biological potential in early oral squamous cell carcinoma.
(PET検査における18F-FDG取り込みは早期口腔扁平上皮癌の生物学的特性と関係する)
Acta Otolaryngol. 2015 May;135(5):494-9. doi: 10.3109/00016489.2014.969385. Epub 2015 Mar 5.

■Kaira K, Toyoda M, Shimizu A, Shino M, Sakakura K, Takayasu Y, Takahashi K, Asao T, Chikamatsu K.
Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.
(腺様嚢胞癌におけるERストレスマーカー(GRP78/BiPとPERK)発現)
Acta Otolaryngol. 2016;136(1):1-7. doi: 10.3109/00016489.2015.1083120. Epub 2015 Sep 14.

■Takahashi H, Sakakura K, Kawabata-Iwakawa R, Rokudai S, Toyoda M, Nishiyama M, Chikamatsu K.
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma.
(頭頸部扁平上皮癌における癌関連線維芽細胞の免疫抑制効果)
Cancer Immunol Immunother. 2015 Nov;64(11):1407-17. doi: 10.1007/s00262-015-1742-0. Epub 2015 Jul 23.

■Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma.
(ステージⅢ/Ⅳ喉頭扁平上皮癌患者におけるアミノ酸トランスポーター(LAT1とASCT2)の発現)
Pathol Oncol Res. 2015 Sep;21(4):1175-81. doi: 10.1007/s12253-015-9954-3. Epub 2015 May 30.

Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K.
Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.
(口腔扁平上皮癌におけるオートファージー分子の増加の免疫学的重要性)
Cancer Sci. 2015 Jan;106(1):1-8. [corresponding author]

■Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.
(CD98はステージⅢ/Ⅳ下咽頭扁平上皮癌の新たな予後因子となる)
Head Neck. 2015 Nov;37(11):1569-74.

■Toyoda M, Kaira K, Ohshima Y, Ishioka NS, Shino M, Sakakura K, Takayasu Y, Takahashi K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer.
(外科的切除された舌癌の予後におけるアミノ酸トランスポーター(LAT1, ASCT2とxCT)の重要性)
Br J Cancer. 2014 May 13;110(10):2506-13. doi: 10.1038/bjc.2014.178. Epub 2014 Apr 24.

■Chikamatsu K, Ishii H, Murata T, Sakakura K, Shino M, Toyoda M, Takahashi K, Masuyama K.
Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌におけるヒストン脱アセチル化酵素阻害薬による癌幹細胞の変化)
Cancer Sci. 2013 Nov;104(11):1468-75. doi: 10.1111/cas.12271. Epub 2013 Oct 1.

■Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Kanai Y, Oyama T, Chikamatsu K.
Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma.
(腺様嚢胞癌患者におけるLAT1の臨床病理学的重要性)
Pathol Oncol Res. 2013 Oct;19(4):649-56. doi: 10.1007/s12253-013-9624-2. Epub 2013 Mar 21.

■Chikamatsu K, Sakakura K, Toyoda M, Takahashi K, Yamamoto T, Masuyama K.
Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌におけるCD14+HLA-DR-細胞の免疫抑制活性)
Cancer Sci. 2012 Jun;103(6):976-83. doi: 10.1111/j.1349-7006.2012.02248.x. Epub 2012 Apr 11.

■Wang X, Katayama A, Wang Y, Yu L, Favoino E, Sakakura K, Favole A, Tsuchikawa T, Silver S, Watkins SC, Kageshita T, Ferrone S.
Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4.
(癌細胞共通表面糖蛋白CSPG4を免疫治療の標的としたscFv-Fc抗体の機能的解析)
Cancer Res. 2011 Dec 15;71(24):7410-22. doi: 10.1158/0008-5472.CAN-10-1134. Epub 2011 Oct 21.

■Chikamatsu K, Ishii H, Takahashi G, Okamoto A, Moriyama M, Sakakura K, Masuyama K.
Resistance to apoptosis-inducing stimuli in CD44+ head and neck squamous cell carcinoma cells.
(CD44陽性頭頸部扁平上皮癌におけるアポトーシス刺激に対する抵抗性)
Head Neck. 2012 Mar;34(3):336-43. doi: 10.1002/hed.21732. Epub 2011 Apr 5.

■Wang X, Osada T, Wang Y, Yu L, Sakakura K, Katayama A, McCarthy J, Brufsky A, Chivukula M, Khoury T, Hsu DS, Lyerly HK, Clay TM, Ferrone S.
CSPG4 as a new target for antibody-based immunotherapy of triple negative breast cancer.
(CSPG4はtriple negative乳癌の抗体免疫療法の新たな標的である)
J Natl Cancer Inst. 2010 Oct 6;102(19):1496-512. Epub 2010 Sep 17

■Chikamatsu K, Takahashi G, Sakakura K, Ferrone S, Masuyama K.
Immunoregulatory properties of CD44+ cancer stem-like cells in squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌患者におけるCD44陽性癌幹細胞の免疫調節的能力)
Head Neck. 2011 Feb;33(2):208-15. doi: 10.1002/hed.21420.

■Ishii H, Chikamatsu K, Sakakura K, Miyata M, Furuya N, Masuyama K.
Primary tumor induces sentinel lymph node lymphangiogenesis in oral squamous cell carcinoma.
(口腔扁平上皮癌の原発巣はセンチネルリンパ節にリンパ管/血管増生を誘導する)
Oral Oncol. 2010 May;46(5):373-8. Epub 2010 Mar 21.

■Chikamatsu K, Sakakura K, Takahashi G, Okamoto A, Furuya N, Whiteside TL, Deleo AB, Masuyama K.
CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer.
(頭頸部扁平上皮癌患者におけるHLA-DP5拘束性野生型p53ペプチドに対するCD4陽性T細胞応答)
Cancer Immunol Immunother. 2009 Sep;58(9):1441-8. Epub 2009 Jan 28.

■Chikamatsu K, Sakakura K, Matsuoka T, Endo S, Takahashi G, Matsuzaki Z, Masuyama K.
Analysis of T-helper responses and FOXP3 gene expression in patients with Japanese cedar pollinosis.
(日本人スギ花粉症患者におけるヘルパーT細胞応答とFOXP3遺伝子発現の解析)
Am J Rhinol. 2008 Nov-Dec;22(6):582-8.

■Okamoto A, Chikamatsu K, Sakakura K, Hatsushika K, Takahashi G, Masuyama K.
Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌患者における癌幹細胞の培養増殖と解析)
Oral Oncol. 2008 Nov 20. 2009 Jul;45(7):633-9. Epub 2008 Nov 21.

Sakakura K, Chikamatsu K, Toyoda M, Kaai M, Yasuoka Y, Furuya N.
Congenital laryngeal anomalies presenting as chronic stridor: A retrospective study of 55 patients.
(慢性的な喘鳴を呈した先天性喉頭奇形:患者55例の後ろ向き解析)
Auris Nasus Larynx. 2008 Dec;35(4):527-33. Epub 2008 Feb 8.

■Chikamatsu K, Sakakura K, Yamamoto T, Furuya N, Whiteside TL, Masuyama K.
CD4+ T helper response in squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌におけるCD4陽性T細胞応答)
Oral Oncol. 2008 Sep;44(9):870-7. Epub 2008 Jan 24.

Sakakura K, Chikamatsu K, Furuya N, Appella E, Whiteside TL, Deleo AB.
Toward the development of multi-epitope p53 cancer vaccines: An in vitro assessment of CD8(+) T cell responses to HLA class I-restricted wild-type sequence p53 peptides.
(多エピトープp53癌ワクチンの開発に向けて:HLAクラスI拘束性野生型p53ペプチドに対するCD8陽性T細胞応答の試験管内評価)
Clin Immunol. 2007 Oct;125(1):43-51. Epub 2007 Jul 12.

■Chikamatsu K, Sakakura K, Whiteside TL, Furuya N.
Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌患者における調節性T細胞とCD8陽性エフェクター細胞との関係)
Head Neck. 2007 Feb;29(2):120-7.

Sakakura K, Chikamatsu K, Shino M, Sakurai T, Furuya N.
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in oral squamous cell carcinoma: possible markers as predictors of clinical outcome.
(口腔扁平上皮癌におけるTSとDPDHの発現:臨床予後因子としての可能性)
Acta Otolaryngol. 2006 Dec;126(12):1295-302.

■Toyoda M, Chikamatsu K, Sakakura K, Fukuda Y, Takahashi K, Miyashita M, Shimamura K, Furuya N.
A case of squamous cell carcinoma of the head and neck producing granulocyte-colony stimulating factor with marked leukocytosis.
(著明な白血球増加を認めたG-CSF産生頭頸部扁平上皮癌の一例)
Auris Nasus Larynx. 2007 Jun;34(2):267-71. Epub 2006 Nov 9.

■Chikamatsu K, Shino M, Sakakura K, Nakajima K, Sakurai T, Miyashita M, Furuya N.
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in adenoid cystic carcinoma of the head and neck: correlation with clinical outcome.
(頭頸部腺様嚢胞癌におけるTSとDPDHの発現:臨床予後との関係)
Oral Oncol. 2007 Aug;43(7):662-9. Epub 2006 Oct 25.

Sakakura K, Takahashi K, Takayasu Y, Chikamatsu K, Furuya N.
Novel method for recording vestibular evoked myogenic potential: minimally invasive recording on neck extensor muscles.
(前庭誘発筋電位の新たな記録法:低侵襲な頸部伸筋での記録)
Laryngoscope. 2005 Oct;115(10):1768-73.

Sakakura K, Chikamatsu K, Takahashi K, Whiteside TL, Furuya N.
Maturation of circulating dendritic cells and imbalance of T-cell subsets in patients with squamous cell carcinoma of the head and neck.
(頭頸部扁平上皮癌患者における末梢血中の樹状細胞の成熟とT細胞サブセットの偏り)
Cancer Immunol Immunother. 2006 Feb;55(2):151-9. Epub 2005 May 12.

Sakakura K, Chikamatsu K, Sakurai T, Takahashi K, Murata T, Oriuchi N, Furuya N.
Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer.
(口腔癌のセンチネルリンパ節への樹状細胞とNK細胞の浸潤)
Oral Oncol. 2005 Jan;41(1):89-96.

Sakakura K, Chikamatsu K, Furukawa M, Shibasaki M, Takegoshi T, Takahashi K, Furuya N.
Acute otitis media caused by drug-resistant bacteria: correlation with antibiotic treatment.
(薬剤耐性菌による急性中耳炎:抗菌薬治療との関係)
Acta Otolaryngol. 2004 Nov;124(9):1008-14.

Sakakura K, Miyashita M, Chikamatsu K, Takahashi K, Furuya N.
Tone burst-evoked myogenic potentials in rat neck extensor and flexor muscles.
(ラットの頸部伸筋と屈筋に見られる音刺激に対する筋電位)
Hear Res. 2003 Nov;185(1-2):57-64.

【英文総説・ガイドライン作成 Review Articles & Guidelines】
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Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, 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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
(オートファジーの検出法と解釈のガイドライン:第3版)
Autophagy. 2016 Jan 2;12(1):1-222.

Sakakura K, Chikamatsu K.
Immune suppression and evasion in patients with head and neck cancer.
(頭頸部癌患者における免疫抑制と監視逃避)
Advances in Cellular and Molecular Otolaryngology 2013, 1: 21809. doi: 10.3402/acmo.v1i0.21809

■Wang X, Wang Y, Yu L, Sakakura K, Visus C, Schwab JH, Ferrone CR, Favoino E, Koya Y, Campoli MR, McCarthy JB, DeLeo AB, Ferrone S.
CSPG4 in cancer: multiple roles.
(癌におけるCSPG4:多様な役割)
Curr Mol Med. 2010 Jun;10(4):419-29.

■Chikamatsu K, Shino M, Fukuda Y, Sakakura K, Furuya N.
Recurring bilateral parotid gland swelling: two cases of sialodochitis fibrinosa.
(反復性両側性耳下腺腫脹:繊維素性唾液腺炎の2例)
J Laryngol Otol. 2006 Apr;120(4):330-3. Review.

【和文雑誌】
坂倉浩一 「当院におけるPRSPの統計的考察」 The Japanese Journal of Antibiotics 2000
坂倉浩一・竹越哲男・柴崎真由美・古川廸代・古屋信彦 「小児の気道感染に伴う薬剤耐性H. influenzaeによる急性中耳炎-市中病院における2年10ヶ月間の症例の検討-」 小児耳鼻咽喉科 2003
岡宮智文・安岡義人・坂倉浩一・古屋信彦 「喉頭喘鳴と気道感染」 小児耳鼻咽喉科 2003
坂倉浩一・安岡義人 「喉頭奇形と手術」 JOHNS 2003
坂倉浩一・安岡義人 「喉頭軟弱症の病態と根治的治療の必要性」 JOHNS 2003
福田洋一郎・近松一朗・坂倉浩一・長井今日子・古屋信彦 「診断に苦慮した好酸球性中耳炎の2症例」 アレルギーの臨床 2005
高橋秀行・坂倉浩一・近松一朗 「頭頸部扁平上皮癌のがん微小環境における癌関連線維芽細胞の役割」 耳鼻咽喉科免疫アレルギー 2016
坂倉浩一 「頭頸部癌患者における骨髄系細胞の動向と制御」 頭頸部癌 2017
坂倉浩一 「免疫チェックポイント分子と頭頸部癌における骨髄系細胞の動向」 耳鼻咽喉科免疫アレルギー 2017

【和文著書】
イラスト手術手技のコツ 耳鼻咽喉科・頭頸部外科 咽喉頭頸部編 「11)喉頭軟弱症の外科的治療-適応と留意点-」 安岡義人・坂倉浩一 東京医学社 2005

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